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Marty Makary: The FDA’s Quiet Blockade on Safer Nicotine
Marty Makary: The FDA’s Quiet Blockade on Safer Nicotine
April 17, 2026
There are moments in public health when the path forward is unusually clear, when the evidence aligns with behavior, and when policy has a genuine opportunity to reduce harm at scale. This should be one of those moments.
What (and How) Should Our Students Be Taught Today?
What (and How) Should Our Students Be Taught Today?
April 16, 2026
There are many – too many – intellectual sources, contemporary as well as throughout the history of the world, from which I could draw to answer it in a very provisional manner, so I’ll have to be selective, but here goes.
Cocooning by Way of the Tdap Vaccine
Cocooning by Way of the Tdap Vaccine
April 15, 2026
Current guidelines (e.g., CDC as of 2025) de-emphasize cocooning as a primary strategy due to implementation challenges and limited evidence supporting standalone effectiveness. Maternal Tdap vaccination during pregnancy is now prioritized for direct antibody transfer to the infant.
To Win at All Costs
To Win at All Costs
April 14, 2026
I was not a close observer of the case, but the win seemed to hinge on documents obtained during discovery that revealed Monsanto knew a great deal about the injuries its product caused but deliberately hid those findings.
This Is Not a Substack
The Hardships That People Mask
April 13, 2026
You never let go. You never abandon your child, no matter what. You keep trying and loving them and that is what I see in the story we’re reading in the news about Nick Reiner’s parents. True love.
What If the FDA Were Eliminated?
What If the FDA Were Eliminated?
April 12, 2026
Reform efforts have been met with frustration. The entire machinery is set up to resist the influence of a politically hostile takeover. For example, Moderna has been given the green light to further develop the technology for a flu shot.
Jury Trials Are Vital to the Constitutional Order
Jury Trials Are Vital to the Constitutional Order
April 11, 2026
The Labour-led British government is attempting to hollow out an ancient pillar of English constitutionalism, trial by jury. Under their reforms, trial by jury would survive in England and Wales for certain types of crimes, but its use would be curtailed.
When War Teaches Medicine
When War Teaches Medicine
April 10, 2026
War is likely to persist. Medicine, however, must remain steadfast, anchored in principles that transcend conflict, ideology, and time. It should not become a weapon but must remain a profession dedicated to the care of each individual, regardless of circumstance.
Medicalization of Our Spiritual Life
Medicalization of Our Spiritual Life
April 9, 2026
Human cultures across time have recognized that certain plants can facilitate contact with the spiritual world—serving as a kind of spiritual nourishment. And yet, more than what we eat, it is our spiritual life that shapes who we truly are.
Don't Use Antidepressants During Pregnancy or for Children
Don't Use Antidepressants During Pregnancy or for Children
April 8, 2026
Official statements that antidepressants are safe to take during pregnancy should be distrusted. No drug is safe. If drugs were safe, they would not be the leading cause of death, ahead of cardiovascular diseases and cancer.
The Story of the Victorian-Era Anti-Mandate Movement
The Story of the Victorian-Era Anti-Mandate Movement
April 7, 2026
All rhetoric and seeming extremism aside, all these movements have ever wanted – from the 1790s to today – is for this product to be subject to normal market discipline of supply and demand, without any interventions designed to back the industry.
What Would Robert Louis Stevenson Say about Ozempic?
What Would Robert Louis Stevenson Say about Ozempic?
April 6, 2026
Today, we have a drug made of "salt forms of a glucagon-like peptide-1 (GLP-1) receptor agonist,” being pushed by physicians and television campaigns and sports heroes and celebrities nationwide that allows people to silence the addict within.
The Lost Art of Medicine: What Maimonides Knew That We Forgot
The Lost Art of Medicine: What Maimonides Knew That We Forgot
April 5, 2026
Contemporary medicine is not failing for lack of knowledge. It is failing under the weight of complexity. Nearly every aspect of patient care can now be measured. Yet despite these advances, a fundamental element has been eroded. This erosion is philosophical.
Not Your Grandfather’s Stagflation
Not Your Grandfather’s Stagflation
April 4, 2026
We are going to get a globe-shaking economic conflagration erupting from the void that was the Persian Gulf commodity fountain. That includes between 20% and 50% of all the basic commodities that drive global GDP.

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